Table 2.

Univariate and multivariate predictors of overall survival in pN0 oesophageal cancer.

Characteristic	Univariate analysis		Multivariate analysis
	HR (95% CI)	P-value	HR (95% CI)	P-value
Age
< 65 years	Reference		Reference
≥ 65 years	0.89 (0.52–1.51)	0.659	0.75 (0.41–1.38)	0.354
Sex
Female	Reference		Reference
Male	0.72 (0.41–1.25)	0.238	0.75 (0.35–1.59)	0.447
Histology
Adenocarcinoma	Reference		Reference
Squamous cell carcinoma	1.35 (0.77–2.36)	0.294	0.31 (0.10–0.99)	0.048*
Tumour location
Upper oesophagus	Reference		Reference
Middle oesophagus	2.21 (0.51–9.69)	0.292	4.76 (0.92–24.61)	0.063
Lower oesophagus	0.66 (0.15–2.94)	0.588	0.95 (0.18–4.87)	0.949
Gastro-oesophageal junction	1.06 (0.25–4.55)	0.940	1.28 (0.25–6.65)	0.772
Histological grade
G1 (well differentiated)	Reference		Reference
G2 (moderately differentiated)	1.85 (0.71–4.85)	0.211	1.66 (0.53–5.25)	0.388
G3 (poorly differentiated)	2.35 (0.89–6.21)	0.086	2.28 (0.76–6.80)	0.141
Presence of lymphovascular invasion
No	Reference		Reference
Yes	1.06 (0.53–2.12)	0.872	1.32 (0.60–2.91)	0.495
Tumour stage (AJCC8)
I	Reference		Reference
II	1.63 (0.90–2.94)	0.105	1.19 (0.59–2.39)	0.635
III	0.74 (0.30–1.83)	0.517	0.36 (0.12–1.10)	0.073
IV	3.54 (0.82–15.26)	0.091	5.98 (1.07–33.56)	0.042*
Number of nodes resected
< 17	Reference		Reference
≥ 17	0.58 (0.34–0.99)	0.048*	0.45 (0.22–0.92)	0.028*
Neoadjuvant radiotherapy
No	Reference		Reference
Yes	2.40 (1.17–4.92)	0.018*	0.70 (0.21–2.32)	0.564
Neoadjuvant chemotherapy
No	Reference		Reference
Yes	1.61 (0.92–2.83)	0.099	3.16 (1.24–8.03)	0.016*
Adjuvant chemotherapy
No	Reference		Reference
Yes	0.66 (2.60–1.66)	0.375	0.35 (0.11–1.12)	0.076

HR hazard ratio, CI confidence interval.

*Significant P-value.