Table 3.

Significant metabolites with the consequent direction of their concentration change between the non-CVD and IHD groups. Metabolites with p-value < 0.05 and AUC score > 0.65 were selected as meaningful.

Metabolite	p-value	Direction	AUC score	Younden index
Acylcarnitine profiling
Hydroxyhexadecanoylcarnitine	< 0.0001	Increased	0.84	1.69
Hydroxyhexadecenoylcarnitine	< 0.05	Increased	0.64	1.68
Hydroxytetradecanoylcarnitine	< 0.001	Increased	0.73	1.68
Adipoylcarnitine	< 0.01	Increased	0.66	1.68
Glutarylcarnitne	< 0.001	Decreased	0.70	1.71
Propionylcarnitine	< 0.05	Decreased	0.63	1.78
Carnitine	< 0.0001	Decreased	0.75	1.98
Tryptophan metabolism pathway
Tryptophan	< 0.05	Decreased	0.63	1.86
Serotonin	< 0.0001	Increased	0.75	1.93
Indole-3-propionic acid	< 0.001	Decreased	0.72	1.84
Indole-3-butyric acid	< 0.01	Decreased	0.68	1.69
Indole-3-carboxaldehyde	< 0.05	Decreased	0.62	1.70
Kynurenic acid	< 0.01	Increased	0.67	1.69
Anthranilic acid	< 0.001	Increased	0.73	1.68
Xanthurenic acid	< 0.05	Increased	0.62	1.69
NO/urea cycle
Asymmetric dimethylarginine	< 0.01	Decreased	0.70	1.83
Arginine	< 0.01	Decreased	0.68	1.91
Citrulline	< 0.01	Decreased	0.67	1.92
Amino acid profiling
Isoleucine	< 0.01	Increased	0.68	1.95
Threonine	< 0.0001	Decreased	0.82	1.99
Histidine	< 0.0001	Decreased	0.80	1.98
Phenylalanine	< 0.0001	Increased	0.79	1.99
Proline	< 0.0001	Decreased	0.74	1.98
Lysine	< 0.001	Decreased	0.72	1.96
Glycine	< 0.01	Decreased	0.68	1.88
Leucine	< 0.05	Increased	0.65	1.95
Aspartic acid	< 0.05	Decreased	0.62	1.69
Asparagine	< 0.01	Decreased	0.67	1.83
3-Aminoisobutyric acid	< 0.05	Increased	0.64	1.96
Tyrosine	< 0.05	Decreased	0.62	1.82
Cystathionine cycle
Cystathionine	< 0.05	Up	0.64	1.73
Methionine sulfoxide	< 0.01	Decreased	0.68	1.80
Norepinephrine	< 0.0001	Decreased	0.76	1.69
Dimethylglycine	< 0.01	Increased	0.66	1.93
Significantly changed ratios
Fischer ratio	< 0.05	Increased	0.65	1.92
GSG ratio	< 0.05	Increased	0.63	1.92