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. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: Int Rev Psychiatry. 2023 Jun 28;35(5-6):377–396. doi: 10.1080/09540261.2023.2229430

Table 5.

Cholecystokinin Antagonists

Study Investigated Drugs (N) Sample Opioid Pain outcomes Duration Findings
McCleane et al., 1998 Proglumide 400mg, Placebo, (Within-subject, N=24) Individuals with chronic neuropathic pain on LTOT. Sustained-release morphine (MST) Pain (VAS) and mobility scores. Treatment: 2 weeks.
Placebo:2 weeks.		 Proglumide caused a small reduction in VAS scores compared to the placebo. Small increase in VAS scores among patients changing from proglumide to placebo.

LTOT: Long-Term Opioid Therapy. VAS: Visual Analog Scales.