Fig. 7.

Exercise induced changes to optoacoustic signals. A-D Distribution of quantitative SWL 800 nm and spectral unmixed deoxygenated hemoglobin (HbR), oxygenated hemoglobin (HbO₂) and multispectral unmixing derived oxygenation (mSO₂) signals before and after exercise. The patients were grouped based on the clinical disease severity (HV; no clinical PAD symptoms, normal ankle-brachial-index (ABI) and palpable foot pulses; IC; combined Fontaine IIa: claudication at a distance > 200 m and IIb: claudication at a distance < 200 m; CLTI; combined Fontaine III: rest pain, mostly in the feet and IV: necrosis and/or gangrene of the limb). E-H Distribution of quantitative SWL 800 nm and spectral unmixed deoxygenated hemoglobin (HbR), oxygenated hemoglobin (HbO₂) and multispectral unmixing derived oxygenation (mSO₂) signals before and after exercise. The patients were grouped based on the angiographic disease severity (aTASC; aTASC1: included as healthy volunteer (HV) with no arteriosclerotic findings in angiography, aTASC 2: assumption of collateralization due to mild findings in aortoiliac (AI) or femoropopliteal (FP) vessel section, aTASC 3: assumption of poor collateralization due to severe AI findings). Dots indicate individual datapoints from patients, error bars indicate mean±SD.