Fig. 2.

Distribution of the multidimensional classifier OSTEO18 in cases (red) and controls (blue) in the derivation (A), replication (B) and time-shifted (C) case-control studies. OSTEO18 was developed by support vector modelling and optimized by take-one-out cross validation procedure. The central line, the upper and lower lines, and the upper and lower whiskers represent the median, interquartile range, and the 10th to 90th percentile interval, respectively. The arithmetic means and extreme measurements are represented by circles inside the box and outside the whiskers, respectively. Arithmetic means and standard deviations are presented along the horizontal axis. n denotes the number of patients in each group. p values denote the significance in the OSTEO18 score between cases and controls in each dataset. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)