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. 2024 Jan 20;10(2):e24867. doi: 10.1016/j.heliyon.2024.e24867

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© 2024 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — Performance of the OSTEO18 classifier on top of other osteoporosis risk factors in 389 uPROPHET patients. n/N indicates the number of patients with osteoporosis and the number of participants at risk (panel A). Base model 1 includes sex, age, the estimated glomerular filtration rate, diabetes (yes vs no) and treatment with methylprednisolone (yes vs no). Base model 2 additionally accounted for the time interval since HTx, ionized calcium, treatment with thiazides (yes vs no), tacrolimus (yes vs no) and cyclosporine (yes vs no). In subsequent steps, OSTEO18 was added to the previous model as a continuously distributed variable (panel B) or as a categorized variable (panel C) based on the 0.095 optimized threshold. At each step, p-values are for the comparison with the preceding model. AUC is the area under curve given with 95 % confidence interval.