Table 2. Pooled Estimates of Performance Indicators for FIT and Colonoscopy-Based Programs.

Variable	Studies, No.	Population, No.	Positive test, No.	Range, %	Point estimate, % (95% CI)a
Participation rate
Overall	12	118 780	105 971	44.5-92.8	85.8 (78.5-91.4)
Voluntary	5	45 699	40 513	77.8-98.2	86.4 (80.9-91.1)
Population-based	4	19 039	17 224	44.5-92.82	83 (58.9-97.7)
Convenience	3	54 042	48 234	88.4-91.24	89.7 (86.8-92.3)
FIT positivity rate
Overall	12	105 971	12 377	5.9-24.9	11.6 (8.7-14.8)
50 ng/dL	5	18 172	3232	9.6-24.9	15.2 (9.6-21.8)
100 ng/dL	5	40 513	5344	5.9-15.2	9.7 (6.8-13.0)
Not reported	2	47 286	3801	8.0-9.1	8 (7.8-8.2)
Detection rates per positive FITb
ADR	12	12 377	3377	5.5-55.07	28.5 (19.1-38.8)
AADR	8	7788	282	1.1-28.2	8.3 (3.5-14.9)
CRC detection rate	12	12 377	410	0.0-12.0	3.5 (1.6-6.0)
Any adenoma (ADR)
FIT-positivec	12	9373	3377	13.9-65.0	39 (29.3-49.2)
Screening colonoscopy	4	3494	699	16.6-26.1	19.9 (15.5-24.8)
Advance Adenoma (AADR)
FIT-positivec	10	7240	648	2.2-34.5	13.3 (7.4-20.5)
Screening colonoscopy	2	2258	62	2.6-3.9	2.9 (1.8-4.3)
CRC detection rate
FIT-positivec	12	9373	420	0.0-15.1	5.4 (3.1-8.2)
Screening colonoscopy	4	3494	15	0.0-1.3	0.4 (0.1-0.8)
Colonoscopy quality indicators
Cecal intubation rate	12	12 203	11 515	86.8-100.0	95.7 (92.7-97.9)
Withdrawal time, mean, min	4	4825	9.9	7.3-17.0	8.4 (4.3-12.4)
Bowel preparation (adequate)	4	6459	6109	83.5-99.6	94.6 (86.6-99.5)

Abbreviations: AADR, advanced adenoma detection rate; ADR, adenoma detection rate (any adenoma); CRC, colorectal cancer; FIT, fecal immunochemical test.

^a Random-effects meta-analysis of proportions.

^b In FIT-based programs.

^c Rates per colonoscopy after positive FIT, from FIT-based programs only.