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. 2024 Jan 23;51(3):48. doi: 10.3892/or.2024.8707

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Copyright: © Pensotti et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Main experimental models. The main experimental models in which tumor reversion processes have been observed were schematically presented. (A) In vivo observation of tumor reversion following graft of cancer cells into healthy tissues (such as liver) following cancer induction on amphibian limbs. (B) In vivo observation of tumor reversion after graft of cancer cells into early stage embryos. (C and D) Induction of tumor reversion after the exposure of cancer cells to soluble factors extracted from (C) embryo microenvironment or (D) produced by embryonic stem cells.