Table 2.
Clinicopathologic characteristics of pT4 patients stratified by treatment
| Population characteristics |
Surgery alone (N = 22) |
Oxaliplatin-based (N = 24) |
P-value |
|---|---|---|---|
| Age (years) | 0.052 | ||
| ≥ 65 | 8(36.4) | 2(8.3) | |
| < 65 | 14(63.6) | 22(91.7) | |
| Gender | 0.840 | ||
| Male | 4(18.2) | 6(25.0) | |
| Female | 18(81.8) | 18(75.0) | |
| Family history | 1.000 | ||
| Yes | 11(50.0) | 12(50.0) | |
| No | 11(50.0) | 12(50.0) | |
| Tumor site | 0.416 | ||
| Right colon | 13(59.1) | 12(50.0) | |
| Left colon | 8(36.4) | 8(33.3) | |
| Multiple primary colorectal | 1(4.5) | 4(16.7) | |
| Lymphatic node number | 0.402 | ||
| < 12 LNs | 10(45.5) | 7(29.2) | |
| ≥ 12 LNs | 12(54.5) | 17(70.8) | |
| LVI | 0.129 | ||
| Yes | 1(4.5) | 6(25.0) | |
| No | 21(95.5) | 18(75.0) | |
| PNI | 0.900 | ||
| Yes | 4(18.2) | 3(12.5) | |
| No | 18(81.8) | 21(87.5) | |
| Histological grade | |||
| Poorly differentiated | 12(54.5) | 12(50.0) | 0.990 |
| Moderately differentiated | 10(45.5) | 12(50.0) | |
| Pre-CEA | 0.606 | ||
| Abnormal (> 5 ng/ml) | 8(36.4) | 6(25.0) | |
| Normal | 14(63.6) | 18(75.0) | |
| Multiple risk factors | 0.702 | ||
| Yes | 19 (86.4) | 19 (79.2) | |
| No | 3(13.6) | 5 (20.8) |
Abbreviations: < 12 LNs Fewer than twelve lymph nodes harvested, LVI Lymphatic vascular invasion, PNI Perineural invasion, Pre-CEA Preoperative carcinoembryonic antigen