Table 3.
Summarized certainty of evidence using the GRADE system
| Outcome | Quality assessment | Absolute effect OR (95% CI) |
Quality | ||||||
|---|---|---|---|---|---|---|---|---|---|
| No. of studies | Design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | |||
| CR | 12 | RCTs | Serious | No serious inconsistency | No serious indirectness | No serious imprecision | None | 2.08 (1.39–3.12) |
⊕ ⊕ ⊕ Ο MODERATE |
| SAE | 9 | RCTs | Serious | No serious inconsistency | No serious indirectness | No serious imprecision | None | 0.70 (0.37–1.33) |
⊕ ⊕ ⊕ Ο MODERATE |
GRADE, Grading of Recommendations, Assessment, Development and Evaluation; CR, clinical remission; SAE, severe adverse events; RCT, randomized controlled trials; OR, odds ratio; CI, confidence interval;