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[Preprint]. 2024 Jan 17:2024.01.15.24301339. [Version 1] doi: 10.1101/2024.01.15.24301339

Figure 2.

Figure 2.

Representative genes expressed in muscle biopsies and cultured myoblasts electroporated with antibodies from myositis patients. Muscle biopsies from all dermatomyositis subgroups (A) and cultured muscle cells with internalized antibodies from 3/5 anti-MDA5-positive patients (B) overexpressed ISG15, a representative IFNB1-stimulated gene. Anti-Mi2-positive muscle biopsies (A) and cultured cells electroporated with antibodies from anti-Mi2-positive patients (B) overexpressed SCRT1, a representative gene from the anti-Mi2-specific gene set. Anti-PM/Scl-positive muscle biopsies (A) and cultured cells electroporated with antibodies from anti-PM/Scl-positive patients (B) overexpressed ENSG00000268403.2, a representative long non-coding RNA from the anti-PM/Scl-specific gene set. Muscle biopsies from anti-synthetase patients (A) and cultured cells electroporated with antibodies from anti-Jo1 patients (B) overexpressed CAMK1G, a member of the anti-Jo1-specific gene set. NT: histologically normal muscle biopsies; DM: dermatomyositis; AS: antisynthetase syndrome; IBM: inclusion body myositis; IM: inflammatory myopathies.