Table 5.

The association between candidate SNPs and ESCC risk in stratified analysis (smoking, drinking, stage, and metastasis).

SNP ID	Model	Genotype	Smoking				Drinking				Stage		Metastasis
			Yes		No		Yes		OR (95% CI)		(III-IV vs I-II)		(Yes vs No)
			OR (95% CI)	pa	OR (95% CI)	pa	OR (95% CI)	pb	OR (95% CI)	pb	OR (95% CI)	P c	OR (95% CI)	P c
rs989902	Allele	T	1		1		1		1		1		1
		G	1.18 (0.90–1.53)	0.230	1.27 (0.99–1.63)	0.059	1.24 (0.96–1.62)	0.106	1.21 (0.94–1.55)	0133	0.84 (0.62–1.14)	0.264	0.81 (0.60–1.10)	0.177
	Genotype	T/T	1		1		1		1		1		1
		G/T	0.97 (0.65–1.46)	0.892	1.39 (0.95–2.03)	0.086	1.31 (0.89–1.93)	0.171	1.36 (0.94–1.97)	0.101	0.97 (0.61–1.54)	0.892	0.61 (0.38–0.97)	0.036*
		G/G	1.42 (0.76–2.66)	0.275	1.45 (0.84–2.48)	0.180	1.50 (0.84–2.67)	0.168	1.37 (0.80–2.33)	0.249	0.63 (0.31–1.27)	0.197	0.75 (0.39–1.46)	0.396
	Dominant	T/T	1		1		1		1		1		1
		G/T-G/G	1.05 (0.71–1.54)	0.811	1.41 (0.98–2.01)	0.062	1.35 (0.93–1.95)	0.111	1.36 (0.96–1.93)	0.081	0.89 (0.57–1.38)	0.593	0.64 (0.41–0.99)	0.046*
	Recessive	T/T-G/T	1		1		1		1		1		1
		G/G	1.44 (0.80–2.60)	0.224	1.21 (0.73–1.99)	0.455	1.29 (0.76–2.21)	0.347	1.16 (0.71–1.91)	0.553	0.64 (0.34–1.23)	0.180	1.00 (0.55–1.83)	0.990
	Log-additive	---	1.12 (0.84–1.49)	0.438	1.25 (0.97–1.61)	0.088	1.25 (0.96–1.63)	0.105	1.22 (0.95–1.56)	0.122	0.84 (0.61–1.16)	0.281	0.79 (0.58–1.09)	0.154
rs738722	Allele	C	1		1		1		1		1		1
		T	1.06 (0.81–1.40)	0.662	1.51 (1.16–1.95)	0.002*	1.40 (1.06–1.85)	0.016*	1.18 (0.91–1.53)	0.214	0.85 (0.62–1.17)	0.327	1.00 (0.73-1.37)	0.986
	Genotype	C/C	1		1		1		1		1		1
		C/T	0.95 (0.64–1.41)	0.813	1.69 (1.16–2.44)	0.006*	1.32 (0.91–1.93)	0.148	1.35 (0.94–1.94)	0.104	0.58 (0.37–0.91)	0.019*	0.86 (0.55–1.34)	0.512
		T/T	1.17 (0.58–2.39)	0.661	1.88 (1.04–3.38)	0.036*	2.17 (1.12–4.24)	0.023*	1.20 (0.67–2.16)	0.542	1.09 (0.54–2.20)	0.803	1.17 (0.58–2.36)	0.669
	Dominant	C/C	1		1		1		1		1		1
		T/C-T/T	0.99 (0.68–1.44)	0.941	1.72 (1.21–2.45)	0.002*	1.44 (1.00–2.06)	0.050	1.32 (0.94–1.86)	0.113	0.66 (0.43–1.02)	0.058	0.92 (0.60–1.39)	0.684
	Recessive	C/C-C/T	1		1		1		1		1		1
		T/T	1.20 (0.60–2.39)	0.605	1.47 (0.84–2.58)	0.178	1.90 (1.00–3.62)	0.050	1.05 (0.60–1.84)	0.874	1.41 (0.73–2.75)	0.309	1.25 (0.64–2.45)	0.511
	Log-additive	---	1.03 (0.76–1.38)	0.868	1.47 (1.13–1.91)	0.004*	1.41 (1.07–1.87)	0.016*	1.18 (0.91–1.53)	0.205	0.86 (0.62–1.18)	0.346	1.00 (0.73–1.37)	0.997

ESCC: esophageal squamous cell carcinoma; SNP: single nucleotide polymorphism; BMI: body mass index; OR: odds ratios; CI: confidence interval

^ap values were calculated by unconditional logistic regression analysis adjusted for age, sex, BMI, and drinking.

^bp values were calculated by unconditional logistic regression analysis adjusted for age, BMI, and smoking.

^cP values were calculated by unconditional logistic regression analysis adjusted for age, sex, BMI, smoking, and drinking.

^*p < 0.05 indicates statistical significance.