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. 1998 Jul;66(7):3423–3428. doi: 10.1128/iai.66.7.3423-3428.1998

TABLE 1.

Immunization schemea

Protein (Aotus monkey) Peptide or compound Sequence
LSA1 (M21) LSA1-J/Lipo ERRAKEKLQEQQSDLEQRKADTKK K(Pam)-NH2b
LSA1-NR DTKKNLERKKEHGDILAEDLYGRLEIP
LSA1-REP LAKEKLQEQQSDLEQERLAKEKLQEQQSDLEQERLAKEKLQ
LSA1-TER NSRDSKEISIIEKTNRESITTNVEGRRDIHKGHKGHL
LSA3 (M23) LSA3-NRI DELFNELLNSVDVNGEVKENILEESQ
LSA3-NRII/Lipo LEESQVNDDIFNSLVKSVQQEQQHNV K(Pam)-NH2
LSA3-RE VESVAPSVEESVAPSVEESVAENVEESV
LSA3-CT1/Lipo LLSNIEEPKENIIDNLLNNI K(Pam)-NH2
SALSA (M4) SALSA-1/Lipo SAEKKDEKEASEQGEESHKKENSQESA K(Pam)-NH2
SALSA-2 NGKDDVKEEKKTNEKKDDGKTDKVQEKVLEKSPK
STARP (M48) STARP-R/Lipo STDNNNTKTISTDNNNTKTI K(Pam)-NH2
STARP-M/Mixotope/Lipo STDNNNTKTISTDNNNTNTI K(Pam)-NH2
L---T-NTIKA---S-IT-N
----D--D-NL------D-T
-------K---------K-K
Adjuvant (V63) Montanide ISA-51
a

Aotus monkeys were immunized with combinations of (i) lipopeptides (Lipo) injected in phosphate-buffered saline without an adjuvant at one location (pooled when there was more than one lipopeptide from each molecule) and (ii) pools of peptides emulsified with Montanide ISA-51 adjuvant (SEPPIC, Paris, France) injected on the same day at another site. STARP-M/Mixotope/Lipo consists of a mixed-epitope degenerated sequence as indicated above and described in reference 20

b

Peptide linked to palmitic acid (Pam) via a lysine residue.