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. Author manuscript; available in PMC: 2024 Feb 2.
Published in final edited form as: Trends Neurosci. 2023 May 9;46(7):539–550. doi: 10.1016/j.tins.2023.04.002

Figure 2. Genetically defined spinally projecting pathways for nociception and pruriception.

Figure 2.

Schematic demonstrating various spinal projection pathways involved in the modulation of nociception and pruriception that have been revealed using cell type-specific measurements and manipulations. Abbreviations: 5HT, 5-hydroxytryptamine; GABA, glutamate decarboxylase; GRPR, gastrin-releasing peptide receptor; LC, locus coeruleus; MdD, medullary reticular nucleus; NE, norepinephrine; NK1R, neurokinin 1 receptor; Penk, proenkephalin; PVN, paraventricular nucleus of hypothalamus; RVM, rostral ventromedial medulla; Tac1, tachykinin 1.