Figure 2. Ligand-receptor interactions between cell types.

(A) Heatmap showing the number of ligand-receptor pairs with a higher score in HS compared with NS among the cell types. Rows, cell type expressing ligand; columns, cell type expressing receptor. ML, myeloid cells; FB, fibroblasts; EC, endothelial cells; KC, keratinocytes; SMC, smooth muscle cells; MLNC, melanocytes; TC, T cells; Mast, mast cells; PLC, plasma cells; BC, B cells. (B–E) Circos plots showing cytokine and growth factor ligand-receptor interactions with higher scores in HS compared with NS in which ligands are expressed by myeloid cells (B), keratinocytes (C), FBs (D), and endothelial cells (E) with receptors expressed by other cell types.