Table I. Peroxisomal proteins that have undergone targeting signal switches.
| Peroxisomal protein | Species | PTS1 consensus | PTS2 consensus | Accession No. | PTS1a of C. elegans orthologue |
|---|---|---|---|---|---|
| 3-Ketoacyl-CoA thiolase |
D. discoidium |
– |
+ |
AU060090 |
|
| |
yeasts |
– |
+b |
|
|
| |
plants |
– |
+b |
|
|
| |
mammals |
– |
+b |
|
|
| |
C. elegans |
+ |
– |
T02G5.8c |
-QKL |
| |
|
|
|
T02G5.7 |
-KKL |
| |
|
|
|
T02G5.4 |
-QKL |
| ADHAPS |
T. brucei |
+ |
– |
AAD19697 |
|
| |
D. discoidium |
+ |
– |
CAA09333 |
|
| |
zebra fish |
– |
+ |
AI667604 |
|
| |
zammals |
– |
+b |
|
|
| |
C. elegans |
+ |
– |
CAA05690.1 |
-CKL |
| Phytanoyl-CoA hydroxylase |
zammals |
– |
+b |
|
|
| |
C. elegans |
+ |
– |
yk151d7.3 |
-ANL |
| Peroxisomal malate dehydrogenase |
S. cerevisiae |
+b |
– |
|
|
| |
plants |
– |
+b |
|
|
| Peroxisomal citrate synthase |
S. cerevisiae |
+b |
– |
|
|
| |
plants |
– |
+b |
|
|
| Acyl-CoA oxidase |
Pichia pastoris |
+b |
– |
|
|
| |
plants |
– |
+b |
|
|
| |
mammals |
+b |
– |
|
|
| |
C. elegans |
+ |
– |
C48B4.1 |
-SKL |
| |
|
|
|
F58F9.7 |
-SKL |
| |
|
|
|
F59F4.1 |
-SKL |
| |
|
|
|
F08A8.3 |
-AKL |
| |
|
|
|
F08A8.2 |
-AKL |
| |
|
|
|
F08A8.1 |
-SKL |
| F08A8.4 | -AKL |
aThe C-termini of all the putative C. elegans orthologues have been shown to be functional in targeting a protein to peroxisomes in other organisms (Gould et al., 1989; Sommer et al., 1992; Motley et al., 1995; Elgersma et al., 1996; Mullen et al., 1997).
bThe functionality of these PTSs has been experimentally validated.
cThe protein encoded by this ORF is the most probable counterpart of the mammalian type I peroxisomal thiolase (Maebuchi et al., 1999).