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General mechanism of JAK inhibition. Adapted from Alexander et al. (2021) [2]. ATP: adenosine-5′-triphosphate; FERM: (4.1 protein, ezrin, radixin, moesin); JAK: Janus kinase; JH: JAK homology; P: phosphate; SH2: Src homology 2-like; STAT: signal transducer and activator of transcription
