Table 2a.

Adjusted Effect of Anxiety on Regional Brain Volumes.

MRI volumetric variables (all continuous)	Anxiety - Yes vs. No (N = 1512)
	B	SE	95% CI	p value	FDR corrected p value
Total white matter volume	3.465	2.363	(−1.171, 8.101)	0.143	0.306
Total brain volume	−0.226	2.529	(−5.187, 4.736)	0.929	0.929
Total brain CSF volume	0.392	2.444	(−4.401, 5.186)	0.873	0.929
Total brain gray matter volume	−3.857	1.740	(−7.270, −0.444)	0.027	0.100
Total brain white matter volume	3.631	2.393	(−1.062, 8.325)	0.129	0.298
Total brain white matter hyperintensity volume	−0.166	0.750	(−1.637, 1.305)	0.824	0.929
Total cerebrum cranial volume	−0.197	1.138	(−2.428, 2.035)	0.863	0.929
Total cerebrum brain volume	−0.878	2.255	(−5.301, 3.545)	0.697	0.909
Total cerebrum CSF volume	0.682	2.160	(−3.555, 4.918)	0.752	0.929
Total cerebrum gray matter volume	−4.439	1.718	(−7.810, −1.069)	0.010	0.042
Total cerebrum white matter volume	3.689	2.297	(−0.817, 8.195)	0.108	0.271
Left hippocampus volume	−0.048	0.026	(−0.098, 0.003)	0.064	0.192
Right hippocampus volume	−0.100	0.025	(−0.150, −0.050)	<0.0001	0.001
Hippocampal volume	−0.147	0.048	(−0.242, −0.053)	0.002	0.014
Left lateral ventricle volume	−0.540	0.646	(−1.808, 0.728)	0.404	0.650
Right lateral ventricle volume	−0.064	0.623	(−1.286, 1.159)	0.918	0.929
Total lateral ventricle volume	−0.606	1.223	(−3.006, 1.793)	0.620	0.846
Total third ventricle volume	0.018	0.030	(−0.042, 0.078)	0.557	0.796
Left frontal lobe cortical gray matter volume	−0.499	0.430	(−1.342, 0.345)	0.246	0.462
Right frontal lobe cortical gray matter volume	−1.050	0.388	(−1.812, −0.289)	0.007	0.034
Total frontal lobe cortical gray matter volume	−1.575	0.792	(−3.129, −0.022)	0.047	0.156
Left occipital lobe cortical gray matter volume	0.264	0.235	(−0.197, 0.725)	0.262	0.462
Right occipital lobe cortical gray matter volume	−0.025	0.235	(−0.486, 0.437)	0.916	0.929
Total occipital lobe cortical gray matter volume	0.261	0.430	(−0.581, 1.104)	0.543	0.796
Left parietal lobe cortical gray matter volume	−0.210	0.256	(−0.711, 0.292)	0.412	0.650
Right parietal lobe cortical gray matter volume	−0.472	0.265	(−0.993, 0.048)	0.075	0.206
Total parietal lobe cortical gray matter volume	−0.681	0.481	(−1.625, 0.263)	0.157	0.315
Left temporal lobe cortical gray matter volume	−0.905	0.298	(−1.489, −0.321)	<0.0001	0.014
Right temporal lobe cortical gray matter volume	−1.240	0.291	(−1.811, −0.670)	<0.0001	0.001
Total temporal lobe cortical gray matter volume	−2.160	0.547	(−3.233, −1.087)	<0.0001	0.001

*adjusted by intracranial volume, sex, age, education, race, Hispanic ethnicity, and cognitive status.