Table 7.
Effect of Ocimum gratissimum Linn. leaf extract (OG), OG petroleum ether fraction (PEOG), OG ethyl acetate fraction (EAOG), OG ethanol fraction (EOG) and valsartan-lisinopril (VAL-LSP) fixed dose combination on the cardiac antioxidant enzyme activities in TZM-treated Wistar rats.
| Treatment Groups | GSH (µmoles/mg protein) |
MDA (ηmoles/mg protein) |
CAT (U/mg protein) |
SOD (U/mg protein) |
GST (U/min/mg protein) |
| Veh. | 63.58 ± 1.56 | 13.25 ± 0.61 | 40.20 ± 0.73 | 1.42 ± 0.04 | 0.53 ± 0.04 |
| Veh. + TZM | 25.57 ± 1.22#- | 27.87 ± 0.74# | 16.97 ± 1.19#- | 0.75 ± 0.08#- | 0.23 ± 0.05#- |
| OG | 40.58 ± 1.83 * | 13.64 ± 0.58 * - | 31.17 ± 1.77 * | 1.18 ± 0.04 * | 0.51 ± 0.03 * |
| OG + TZM | 38.32 ± 0.92 * | 15.96 ± 0.56 * - | 28.51 ± 1.34 * | 1.32 ± 0.05 * | 0.42 ± 0.03 * |
| PEOG | 47.94 ± 3.50 * | 17.93 ± 1.36 * - | 27.54 ± 1.11 * | 1.48 ± 0.10 * | 0.48 ± 0.07 * |
| PEOG + TZM | 44.19 ± 2.12 * | 17.56 ± 2.76 * - | 26.61 ± 2.34 * | 1.60 ± 0.16 * | 0.41 ± 0.08 * |
| EAOG | 42.41 ± 1.26 * | 15.07 ± 0.44 * - | 25.57 ± 0.41 * | 1.38 ± 0.08 * | 0.44 ± 0.05 * |
| EAOG + TZM | 39.31 ± 1.07 * | 17.12 ± 1.08 * - | 23.73 ± 0.44 * | 1.78 ± 0.11 * | 0.44 ± 0.02 * |
| EOG | 39.73 ± 2.57 * | 14.45 ± 0.42 * - | 28.23 ± 1.49 * | 1.45 ± 0.08 * | 0.51 ± 0.06 * |
| EOG + TZM | 32.97 ± 1.68 * | 16.82 ± 0.96 * - | 25.12 ± 1.48 * | 1.56 ± 0.20 * | 0.48 ± 0.05 * |
| VAL-LSP | 39.92 ± 1.11 * | 14.30 ± 0.63 * - | 27.28 ± 0.44 | 1.44 ± 0.37 * | 0.45 ± 0.07 * |
| VAL-LSP+ TZM | 38.82 ± 1.99 * | 18.72 ± 0.79 * - | 25.75 ± 2.03 * | 1.69 ± 0.14 * | 0.41 ± 0.03 * |
Values represents mean ± SEM (n = 5)
# and #-represents a significant increase and decrease at p < 0.05, respectively, when compared to values for the Veh.only-treated group while * and *- represent a significant increase and decrease at p < 0.05, respectively, when compared to values for the Veh. + TZM-treated group.
Veh. – 10 ml/kg/day distilled water p.o. + 1 ml/kg/day distilled water i.p.
Veh. + TZM – 10 ml/kg/day distilled water p.o. + 2.25 mg/kg/day TZM i.p.
OG – 100 mg/kg/day OG p.o. + 1 ml/kg/day distilled water i.p.
OG + TZM – 100 mg/kg/day OG p.o. + 2.25 mg/kg/day TZM i.p.
PEOG – 100 mg/kg/day PEOG p.o. + 1 ml/kg/day distilled water i.p.
PEOG + TZM - 100 mg/kg/day PEOG p.o. + 2.25 mg/kg/day TZM i.p.
EAOG - 100 mg/kg/day EAOG p.o. + 1 ml/kg/day distilled water i.p.
EAOG + TZM - 100 mg/kg/day EAOG p.o. + 2.25 mg/kg/day TZM i.p.
EOG - 100 mg/kg/day EOG p.o. + 1 ml/kg/day distilled water i.p.
EOG + TZM - 100 mg/kg/day EOG p.o. + 2.25 mg/kg/day TZM i.p.
VAL-LSP – 5 mg/kg/day VAL-0.035 mg/kg/day LSP fixed-dose combination p.o. + 1 ml/kg/day distilled water i.p.
VAL-LSP + TZM – 5 mg/kg/day VAL-0.035 mg/kg/day LSP fixed-dose combination p.o. + 2.25 mg/kg/day TZM i.p.