2016 WHO Diagnostic Criteria For CMML
1.Presence of persistent (>3 months) peripheral blood monocytosis ≥1 × 109/L with monocytes constituting ≥10% of the white blood cell count differential.
2.Not meeting WHO criteria for BCR-ABL1 driven chronic myeloid leukemia, essential thrombocythemia, polycythemia vera, or primary myelofibrosis
3.No evidence for PDGFRA or PDGFRB rearrangements, and the absence of FGFR1 rearrangements or the PCM1-JAK2 fusion in the context of concomitant eosinophilia
4.<20% blasts/blasts equivalent (promonocytes, monoblasts, and myeloblasts) in the peripheral blood and bone marrow.
5.Dysplasia in 1 or more myeloid cell lineages. If myelodysplasia is absent or minimal, the diagnosis of CMML may still be made if the other requirements are met and (see point 6).
6.An acquired clonal cytogenetic or molecular genetic abnormality (TET2, ASXL1, SRSF2, and SETBP1) is present in hematopoietic cells.

Abbreviations: CMML, chronic myelomonocytic leukemia; WHO, World Health Organization.