TABLE 2.
Antibody titers and day 5 parasitemias in C57BL/6 mice after immunization with PyMSP-1 DNA vaccines and challenge with sporozoites
| Immunogen(s) | Titera | Parasitemia (%)b |
|---|---|---|
| tPA–p2p30–C-term | 1:1,280 | 0.49 |
| PyMSP-1 | 1:40 | 0.10 |
| tPA–p2p30–C-term + PyMSP-1 | 1:1,280 | 0.59 |
| tPA–p2p30–C-term + tPA–PyMSP-1 | 1:2,560 | 0.36 |
| tPA–p2p30–C-term + tPA–p2p30–N-term | 1:2,560 | 0.46 |
| Vector control | Neg | 0.55 |
| MSP-19 recombinant protein | 1:5,120 | 0.12 |
a
Antibody titers in pooled sera were determined by IFAT on air-dried P. yoelii-infected erythrocytes 4 days prechallenge. Neg, negative.
b
Values are geometric mean parasitemias on day 5 postchallenge.