Table 1.

Evolution of criteria for acromegaly diagnosis and evaluation of therapeutic efficacy

	Diagnosis	Therapeutic efficacy target
1st Acromegaly consensus [3]	IGF-I elevated for age and sex Confirm with random GH ≥ 0.4 µg/L or IGF-I elevated for age and sex Confirm with GH > 1 µg/L during OGTT	IGF-I normalized for age and sex GH < 1 µg/L during OGTT
7th Acromegaly consensus [4]	IGF-I elevated for age and sex and Random GH elevated	Random GH < 1 µg/L GH < 0.4 µg/L during OGTT
Endocrine society guidelines [5]	IGF-I elevated for age Confirm with GH > 1 µg/L during OGTT	IGF-I normalized for age Random GH < 1 µg/L
14th Acromegaly consensus (this publication)	IGF-I > 1.3 × ULN for age and Characteristic clinical signs of disease For equivocal results, IGF-I measurements can be repeated, and OGTT might additionally be useful	IGF-I normalized for age

GH growth hormone; IGF-I insulin-like growth factor I; OGTT oral glucose tolerance test; ULN upper limit of normal