. 2023 Nov 3;27(1):7–22. doi: 10.1007/s11102-023-01360-1

Table 4.

Grading of evidence and recommendations

Evidence	Very low quality (VLQ): expert opinion supported by one or few small uncontrolled studies
	Low quality (LQ): supported by large series of small uncontrolled studies
	Moderate quality (MQ): supported by one or few large uncontrolled studies or meta-analyses
	High quality (HQ): supported by controlled studies or large series of large uncontrolled studies with sufficiently long follow-up
Recommendations	Discretionary: based on VLQ or LQ evidence
Recommendations	Strong: based on MQ or HQ evidence

Based on principles for grading of evidence for guidelines and prior Acromegaly Consensus publications [9–11]