Figure 6.

Mito‐transfer in naïve CD4 T cells from old mice protects mice against pathogens & promotes protective T cell phenotypes. A) 2.0 x 10⁶ naïve CD4⁺ T cells from old mice with or without mito‐transfer, or PBS were tail vein injected in Rag1‐KO mice that were subsequently infected with either IAV or M.tb. Rag1‐KO mice infected with IAV were monitored for B) disease body weight (morbidity) and C) survival (mortality). After 21 days of infection, D) the lung and spleen of Rag1‐KO mice infected with M.tb were processed to determine M.tb CFU burden.