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. 2023 Dec 3;11(5):2305063. doi: 10.1002/advs.202305063

Figure 4.

Figure 4

The evaluation of penetration ability of DPNMs. A) The IVIS imaging of Cy5‐labelled DPNMs in rats and B) the quantification of mean fluorescence intensity (MFI). Data are presented as mean ± SD (n = 3, one‐way ANOVA and Sidak's multiple comparison tests, **p < 0.01 versus ZIF‐8 group). C) 3D CLSM images and corresponding z‐stack images of mixed bacteria biofilms treated with Cy5‐labeled ZIF‐8 and DPNMs for 3 and 10 min. Scale bar: 30 µm. D) 3D CLSM images of mixed bacteria biofilms (green fluorescence: mixed bacteria biofilms stained with SYTO 9; red fluorescence: PI). Scale bar: 10 µm. E) The quantitative analysis of the dead/live ratio of bacteria. Data are presented as mean ± SD (n = 3). F) Illustration of NO‐propelled penetration in pulp tissue and biofilms.