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. 2024 Feb 2;11:159. doi: 10.1038/s41597-024-03002-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Evaluating the similarity among the BE1-500 pseudo-bulks and the pseudo-bulks generated for lung cancer single cell data³⁵ and CCLE cell line bulk transcription profiling. (A) Tian’s single cell RNA-seq experiment³⁵. This dataset includes: H2228 (PTPN3 KO³³, EML4-ALK Fusion⁴⁰), H1975 (EGFR L858R and T790M mutations⁴¹), A549 (KRAS p.G12S, growth and proliferation¹⁴), H838 (KRASp.G12D⁴²) and HCC827 (EGFR L858R mutation⁴³) cell lines. (B) pseudo-bulk data derived from scRNA-seq published by Aissa et al.³⁶ and Clark et al.³⁷.