Table I. Properties of inhibitors affecting MAPK family members and calcineurin.

	Inhibition of					Binding to immunophilin	References
	ERK	JNK	p38	Cn a	NFAT
CsA	no	yes	yes	yes	yes	yes	Schreiber (1992)
							Su et al. (1994)
							Matsuda et al. (1998)
FK506	nob	yes	yes	yes	yes	yes	Schreiber (1992)
A238L	no	yes	yes	yes	yes	yes	Miskin et al. (1998)
FR901725c	no	no	no	yes	yes	no
Cabin1	no	no	no	yes	yes	no	Lai et al. (1998)
							Sun et al. (1998)
LL-Z1640-2	no	yes	yes	no	no	no	Takehana et al. (1999)
SB203580	no	no	yes	no	no	no	Lee et al. (1994)

^aCalcineurin.

^bUnderlined results were obtained in this work.

^cThis reagent does not affect other phosphatases such as PP2A (H. Mori, F. Abe, M. Hashimoto, S. Takase, M. Hino and S. Hashimoto, in preparation).