Table 1.
Baseline Demographic and Clinical Characteristics of the Included Patients
| Characteristic | All Patients (n=68) | Effective Group (n=48) | Ineffective Group (n=20) |
|---|---|---|---|
| Age, years (IQR) | 80.0(73.0–84.8) | 78.5(71.2–83.0) | 79.2(79.2–86.0) |
| Male sex (n, %) | 51(75.0) | 36(70.6) | 15(29.4) |
| BMI, kg/m2 (IQR) | 23.5(22.0–26.1) | 24.1(22.1–27.4) | 23.4(22.0–24.6) |
| Clinical classification | |||
| Medium (n, %) | 38(55.9) | 36(75.0) | 2(10.0) |
| Severe (n, %) | 11(16.2) | 9(18.8) | 2(10.0) |
| Critical (n, %) | 19(27.9) | 3(6.2) | 16(80.0) |
| APACHE II score (IQR) | 10.0(7.0–13.8) | 8.0(7.0–11.0) | 15.0(12.0–19.0) |
| eGFR, mL/min (IQR) | 80.5(63.8–95.8) | 78.5(69.5–98.0) | 82.0(56.2–91.8) |
| Albumin, g/L (IQR) | 32.6(29.9–35.9) | 34.2(30.8–36.0) | 30.5(29.7–32.1) |
| TBil, μmol/L (IQR) | 9.0(5.9–11.6) | 7.9(5.4–10.9) | 10.6(9.3–14.0) |
| ALT, U/L (IQR) | 36.5(22.2–51.0) | 33.0(20.5–46.8) | 44.0(24.8–65.8) |
| AST, U/L (IQR) | 25.5(16.5–40.5) | 21.0(15.0–31.8) | 39.0(32.0–58.8) |
| r-GT, U/L (IQR) | 40.5(30.0–64.2) | 39.0(27.0–60.8) | 53.0(34.5–139.0) |
| LDH, U/L (IQR) | 293.0(226.8–335.5) | 267.5(208.0–301.0) | 384.5(294.5–467.5) |
| TC, mmol/L (IQR) | 4.4(4.0–4.9) | 4.4(4.1–4.9) | 4.4(3.6–4.5) |
| Concomitant disease | |||
| Diabetes (n, %) | 39(57.4) | 25(52.1) | 14(70.0) |
| Hypertension (n, %) | 17(25.0) | 10(20.8) | 7(35.0) |
| Abnormal liver function (n, %) | 6(8.8) | 4(8.3) | 2(10.0) |
| Cancer (n, %) | 12(17.6) | 11(22.9) | 1(5.0) |
| Drug combination (n, %) | 18(26.5) | 13(27.1) | 5(25.0) |
| ADR (n, %) | 4(5.9) | 4(8.3) | 0(0.0) |
| Nirmatrelvir, μg/mL (IQR) | 5.1(2.6–7.1) | 4.6(2.3–6.4) | 5.6(4.4–4.2) |
| Ritonavir, μg/mL (IQR) | 0.4(0.2–0.9) | 0.4(0.1–0.8) | 0.7(0.2–1.2) |
| Length of stay, days (mean±SD) | 18.47±11.18 | 17.92±8.28 | 19.8±16.37 |
Abbreviations: IQR, interquartile range; eGFR, estimated glomerular filtration rate; TBil, total bilirubin; ALT, alanine aminotransferase; AST, aspartate transaminase; r-GT, r-glutamyltransferase; LDH, lactate dehydrogenase; TC, total cholesterol; ADR, adverse drug reaction; SD, standard deviation.