Fig. 5. GAUDI performance compared to pPRS, PRS-CSx and PRSice in external evaluations for different traits.
a CRP and WBC; b other continuous traits; c binary diseases. The models were trained using UKB participants with African ancestry, and applied to WHI AA individuals. Each analysis was repeated five times, using five different testing sets. The center of each bar plot represents the mean R2 across five folds, with the error bar denoting the standard deviation across the five replicates. CRP C-reactive protein, WBC White blood cell count, HCT Hematocrit, HGB Hemoglobin, PLT Platelet count. Source data are provided as a Source Data file.