Table 1.

Reports on drug resistance of ECs by tumor-derived EVs

Donor cell	Recipient cell	Relevant EV cargo	Target gene	Mechanism	Ref.
A375SM cells	HMVECs	miR-1246	Androgen receptor	miR-1246 increases IL-6 expression by targeting the androgen receptor and activating Akt and STAT3	[78]
Adriamycin-resistant MCF-7 cells	HMECs	TrpC5, P-gp	-	TrpC5 incorporated into EC induces P-gp expression via translocation of NFATc3	[79]

ECs: Endothelial cells; EVs: extracellular vesicles; A375SM: highly metastatic melanoma cell; HMVEC: human dermis microvascular endothelial cell; STAT3: signal transducer and activator of transcription 3; MCF7: breast cancer cell; HMEC: human microvessel endothelial cell; P-gp: P-glycoprotein; TrpC5: transient receptor potential channel 5; NFATc3: nuclear factor of activated T cells isoform c3.