Aramayo 1990.
Methods | Single‐centre RCT. | |
Participants | 30 women. Inclusion criteria: in preterm labour between 28‐36 weeks' gestation with intact membranes. The diagnosis of labour was made if persistent uterine contractions occurred 3 times in 10 minutes and cervical examination suggested 'active labour'. Gestational age range: 28‐36 weeks. Exclusion criteria: cervical incompetence, congenital malformation, ruptured membranes, fetal death, maternal cardiac disease. Setting: Mexico, 1988‐1989. |
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Interventions |
MAGNESIUM VS BETAMIMETICS 1) magnesium sulphate (n = 15): loading dose 4 g IV; maintenance 2 g/hr; 2) terbutaline for labour inhibition (n = 15): 1.25 mg in 500 mL dextrose given at 10 drops per minute; followed by 5 mg oral tablet 8 hourly. |
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Outcomes | Postponement of birth for at least 48 hrs after initiation of therapy; 2‐6 days, 7‐12 days, > 12 days after treatment; preterm birth. | |
Notes | Antenatal corticosteroid use: not stated.
Surfactant use: not stated. Sample size calculation: not stated. Funding: not stated. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | "randomised study." |
Allocation concealment (selection bias) | Unclear risk | "randomised study"; no further details reported. |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Not feasible to blind the interventions. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | No mention of outcome assessors being blinded. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | 1 woman in the terbutaline group was excluded because of severe fetal distress. |
Selective reporting (reporting bias) | Unclear risk | Only infant outcome reported was preterm birth; no maternal health outcomes reported. |
Other bias | Low risk | No apparent evidence of other bias. |