Asgharnia 2002.
Methods | RCT. | |
Participants | 120 pregnant women. Inclusion criteria: pregnant women with intact membranes and preterm labour, with cervical dilatation of at least 2 cm. Exclusion criteria: premature rupture of membranes, GA < 24 or > 32 weeks, complete cervical dilatation, severe haemorrhage, chorioamnionitis and triple or higher order gestation. Setting: Gilan University, Iran. |
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Interventions |
MAGNESIUM VS PROSTAGLANDIN INHIBITORS 1) magnesium sulphate, loading dose 4 g IV followed by 2 g/hr until uterine activity diminished (assume n = 60); 2) indomethacin, 25 mg every 6 hrs for 4 doses (assume n = 60). |
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Outcomes | Delay in birth (24 and 48 hrs); maternal complications. | |
Notes | Antenatal corticosteroid use: not stated.
Surfactant use: not stated. Sample‐size calculation: not stated. Funding: not stated. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | "randomly managed" ‐ no further details given. |
Allocation concealment (selection bias) | Unclear risk | "randomly managed" ‐ no further details given. |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Not reported but not likely to have been feasible. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not reported. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Not reported. |
Selective reporting (reporting bias) | High risk | Numbers of women in each group were not reported; the only outcomes reported were delay in birth at 24 and 48 hrs; and complications (reported only that there were none but individual complications were not listed). |
Other bias | Low risk | Similar baseline characteristics. |