Table III. Carrier and estimated haplotype frequencies of hPer3 polymorphisms in patients and controls.
| Haplotype | Carrier frequency (%) |
Haplotype frequency (%) |
|||||
|---|---|---|---|---|---|---|---|
| DSPS | N-24 | Controls | DSPS | N-24 | Controls | ||
| H1[V647,P864,4-repeat,M1037,H1158] | 40/48 (83.3) | 28/30 (93.3) | 89/100 (89.0) | 62/96 (64.6) | 42/60 (70.0) | 137/200 (68.5) | |
| H2[V647,P864,5-repeat,M1037,H1158] | 16/48 (33.3) | 7/30 (23.3) | 34/100 (34.0) | 19/96 (19.8) | 7/60 (11.7) | 39/200 (19.5) | |
| H3[V647,A864,4-repeat,T1037,H1158] | 7/48 (14.6) | 10/30 (33.3) | 19/100 (19.0) | 8/96 (8.3) | 10/60 (16.7) | 22/200 (11.0) | |
| H4[G647,P864,4-repeat,T1037,R1158] | 7/48 (14.6)a | 1/30 (3.3) | 2/100 (2.0) | 7/96 (7.3)b | 1/60 (1.7) | 2/200 (1.0) | |
Underlined are minor alleles in each polymorphic locus.
Statistical comparisons were performed using a two-tailed Fisher’s exact test.
aP = 0.0055 versus controls, Bonferroni’s corrected P = 0.033.
bP = 0.0062 versus controls, odds ratio = 7.79, 95% CI 1.59–38.3, Bonferroni’s corrected P = 0.037.