Table 3.

Asymptomatic and Symptomatic Viral Infections, Odds Ratio of Symptomatic Infection, and Attributable Fraction in the PREVAIL Cohort (N = 245), by Respiratory Virus

Pathogena	Viral Infectionsb	Asymptomatic Infections	Symptomaticc Infections	Odds of Symptomatic Infection, Compared With All Other Pathogens (95% CI)	P	Attributable Fraction in Exposed (95% CI)
RSV B	37	6	31	8.89 (3.94, 20.05)	<001	89% (75%, 95%)
Parainfluenza 2	16	4	12	6.36 (1.96, 20.65)	.002	84% (49%, 95%)
RSV A	47	14	33	4.97 (2.66, 9.28)	<001	80% (62%, 89%)
Influenza A	26	9	17	3.85 (1.60, 9.22)	.003	74% (38%, 89%)
Influenza B	5	2	3	3.69 (.71, 19.11)	.119	73% (−41%, 95%)
Parainfluenza 1	19	8	11	2.91 (1.15, 7.40)	.025	66% (13%, 86%)
Parainfluenza 4	37	17	20	2.52 (1.29, 4.93)	.007	60% (23%, 80%)
Parainfluenza 3	67	33	34	2.09 (1.32, 3.30)	.002	52% (24%, 70%)
Human metapneumovirus	56	28	28	2.05 (1.20, 3.49)	.009	52% (17%, 71%)
Adenovirus	68	34	34	1.81 (1.04, 3.15)	.036	45% (4%, 68%)
Coronavirus OC43	61	41	20	.91 (.52, 1.59)	.736	−10% (−92%, 37%)
Coronavirus NL63	45	31	14	.86 (.49, 1.51)	.596	−16% (−104%, 34%)
Coronavirus HKU1	40	28	12	.75 (.38, 1.50)	.417	−33% (−163%, 33%)
Rhinovirus/enterovirus	822	602	220	.45 (.36, 0.56)	<.001	−122% (−178%, −79%)
Bocavirus	115	97	18	.36 (.22, 0.60)	<001	−178% (−355%, −67%)
Coronavirus 229E	9	8	1	.22 (.02, 3.02)	.258	−355% (−4900%, 67%)

P values ≤ 0.05 bolded.

Abbreviations: CI, confidence interval; PREVAIL, Pediatric Respiratory and Enteric Virus Acquisition and Immunogenesis Longitudinal; RSV, respiratory syncytial virus.

^aOrdered by odds ratio of symptomatic infection, highest to lowest.

^bViral infections without co-detection of multiple respiratory viruses (n = 1470).

^cSymptomatic is defined as the presence of fever and/or cough with or without the presence of other respiratory or gastrointestinal symptoms.