Table 4.
Age at First Viral Infection and Proportion of Cohort Who Experienced at Least 1 Respiratory Viral Infection Detected by PCR of a Nasal Swab in the Highly Adherent PREVAIL Cohort (n = 101), by Respiratory Virus
| Proportion of Cohort With at Least 1 Viral Infection Detected by Nasal Swab | |||
|---|---|---|---|
| Pathogen | Age at First Viral Infection,a mo | By 12 Months | By 24 Months |
| Adenovirus | 8 (6–11)b | 48% | 59% |
| Bocavirus | 10 (6–15)c | 50% | 77% |
| Endemic coronavirus | 11 (6–17) | 55% | 79% |
| 229E | 18 (11–19) | 3% | 9% |
| HKU1 | 13 (7–18) | 20% | 45% |
| NL63 | 11 (5–15.5) | 23% | 44% |
| OC43 | 11 (6–13) | 31% | 50% |
| Influenza virus | 17 (10–20) | 11% | 27% |
| Influenza A | 17 (10–20) | 9% | 25% |
| Influenza B | 11.5 (6–20) | 2% | 4% |
| Human metapneumovirus | 11 (8–18) | 24% | 47% |
| Parainfluenza virus | 12 (7–17) | 50% | 82% |
| PIV1 | 18.5 (15–21.5) | 3% | 20% |
| PIV2 | 9 (7–13) | 9% | 17% |
| PIV3 | 10 (6–14) | 38% | 57% |
| PIV4 | 15 (9–19) | 10% | 31% |
| Rhino/enterovirus | 2 (1–3)d | 97% | 100% |
| Respiratory syncytial virus | 12 (7–18) | 40% | 66% |
| RSV A | 15.5 (9–19) | 16% | 42% |
| RSV B | 9 (6–17) | 25% | 41% |
Abbreviations: PCR, polymerase chain reaction; PREVAIL, Pediatric Respiratory and Enteric Virus Acquisition and Immunogenesis Longitudinal; RSV, respiratory syncytial virus.
Presented as median (interquartile range).
Significantly differs from median age at first viral infection of influenza virus (P = .005), parainfluenza virus (P = .013), and RSV (P = .018).
Significantly differs from median age at first viral infection of influenza virus (P = .005).
Significantly differs from median age at first viral infection of all other respiratory virus using Kruskal–Wallis, P ≤ .0001.