Table 2.
Univariate and multivariate analyses of prognostic factors associated with OS and DFS
| Variable | Overall survival | Disease-free survival | ||||
|---|---|---|---|---|---|---|
| Univariate P-value | Multivariate P-value | Multivariate HR (95% CI) | Univariate P-value | Multivariate P-value | Multivariate HR (95% CI) | |
| Age, year (≥ 60 vs. < 60) | 0.515 | NA | NA | 0.825 | NA | NA |
| Gender (male vs. female) | 0.405 | NA | NA | 0.494 | NA | NA |
| Anatomic site (acra vs. trunk vs. other) | 0.739 | NA | NA | 0.949 | NA | NA |
| Histologic type (superficial reading vs. nodular vs. acral vs. lentigo maligna) | 0.056 | NA | NA | 0.104 | NA | NA |
| Breslow depth (mm) (> 2 vs. ≤ 2) | 0.088 | NA | NA | 0.032 | 0.358 | 1.234 (0.789–1.930) |
| Clark level (IV–V vs. I–III) | 0.001 | 0.100 | 1.494 (0.925–2.412) | 0.001 | 0.041 | 1.606 (1.019–2.531) |
| Ulceration (present vs. absent) | 0.160 | NA | NA | 0.176 | NA | NA |
| Lymph node metastasis (yes vs. no) | < 0.001 | 0.728 | 0.697 (0.091–5.336) | < 0.001 | 0.953 | 0.940 (0.121–7.331) |
| Distant metastasis (yes vs. no) | 0.003 | 0.553 | 0.547 (0.075–4.014) | 0.007 | 0.815 | 0.788 (0.108–5.775) |
| Clinical stage (III–IV vs. I–II) | < 0.001 | 0.001 | 2.699 (1.468–4.961) | < 0.001 | 0.014 | 2.164 (1.170–4.001) |
| circFCHO2 expression (high vs. low) | 0.005 | 0.021 | 1.667 (1.079–2.577) | 0.006 | 0.034 | 1.600 (1.037–2.467) |
A chi-square test was used for comparing groups between low and high circFCHO2 expression. *P < 0.05 was considered significant