DALYs	disability-adjusted life-years
SSRIs	selective serotonin reuptake inhibitors
SNRIs	serotonin and norepinephrine reuptake inhibitors
MAOIs	monoamine oxidase inhibitors
MDD	major depressive disorder
TCM	traditional Chinese medicine
LPS	lipopolysaccharide
Ber	berberine
HPA	hypothalamic-pituitary-adrenal
CNKI	Chinese National Knowledge Infrastructure
TCAs	tricyclic antidepressants
5-HT	serotonin
NE	noradrenaline
CNS	central nervous system
MAO	monoamine oxidase
DA	dopamine
HPLC	high-performance liquid chromatography
ELISA	enzyme-linked immunosorbent assay
5-HTT	5-HT transporter
TH	tyrosine hydroxylase
TPH1	tryptophan 5-hydroxylase-1
IDO1	indoleamine 2,3-dioxygenase-1
KYN	kynurenine
SGZ	subgranular zone
DG	dentate gyrus
miR	microRNA
JNK	Jun N-terminal kinase
CREB	cyclic adenosine monophosphate
IGFR	insulin-like growth factor receptor
BDNF	brain-derived neurotrophic factor
OFT	open-field test
eEF2	elongation factor 2
CRF	corticotrophin-releasing factor
ACTH	adrenocorticotrophin
GC	glucocorticoid
CUMS	chronic unpredictable mild stress
CORT	corticosterone
FST	forced swimming test
SPT	sucrose preference test
EPM	elevated plus maze
ROS	reactive oxygen species
MDA	malondialdehyde
SOD	superoxide dismutase
GSH-Px	glutathione peroxidase
CAT	catalase
T2DM	type 2 diabetes mellitus
SIRT1	sirtuin1
FoxO	forkhead box protein O
Nrf2	nuclear factor erythroid 2-related factor 2
BBB	blood-brain barrier
TNF-α	tumor necrosis factor-α
IL-6	interleukin-6
IFN-γ	interferon-γ
CRP	C-reactive protein
RIG-I	retinoic acid-inducible gene I
NSFT	novelty-suppressed feeding test
NOS	nitric oxide synthases
TRIM	tripartite motif
TST	tail suspension test
HL	Huang Lian
JTW	jiao-tai-wan
CRS	chronic restraint stress
HLJDD	HuangLian JieDu Decoction
ZJP	Zuojin pill
BXXXD	Banxia Xiexin Decoction
P-gp	P-glycoprotein
CYPs	cytochrome P450s
LD 50	median lethal dosage