Table 3.
Fecal microbiota: relative abundance differences at the genus level.
| Genus | % of relative abundance | Adjusted p. values | Plasma cholesterol | |||||
|---|---|---|---|---|---|---|---|---|
| ND | WD | WD-T070 3 g/kg | ND vs. WD | ND vs. WD-T070 3 g/kg | WD vs. WD-T070 3 g/kg | Person | Adjusted p. values | |
| uncl. Bifidobacteriaceae | 1.05 ± 0.58 | 0.07 ± 0.10 | 0.10 ± 0.10 | 0.0067 | 0.0133 | 0.5270 | −59.4% | 0.0058 |
| Bifidobacterium | 6.63 ± 4.43 | 0.30 ± 0.38 | 0.57 ± 0.62 | 0.0065 | 0.0099 | 0.4050 | −55.4% | 0.0119 |
| uncl. Coriobacteriia | 0.03 ± 0.03 | 0.02 ± 0.01 | 0.09 ± 0.07 | 0.7760 | 0.0652 | 0.0360 | 4.6% | 0.8128 |
| Bacteroides | 0.61 ± 0.35 | 1.93 ± 1.26 | 1.74 ± 0.89 | 0.0067 | 0.0133 | 1.0000 | 52.9% | 0.0137 |
| uncl. Bacteroidaceae | 0.10 ± 0.08 | 0.30 ± 0.24 | 0.45 ± 0.16 | 0.0598 | 0.0065 | 0.1645 | 46.4% | 0.0322 |
| Phocaeicola | 0.67 ± 0.52 | 1.71 ± 1.36 | 7.79 ± 2.29 | 0.1621 | 0.0058 | 0.0111 | 32.1% | 0.1549 |
| uncl. Muribaculaceae | 6.86 ± 1.95 | 5.39 ± 1.20 | 7.85 ± 1.06 | 0.1636 | 0.2233 | 0.0162 | −29.0% | 0.1998 |
| Paramuribaculum | 0.25 ± 0.20 | 0.41 ± 0.20 | 0.01 ± 0.01 | 0.2441 | 0.0058 | 0.0096 | 18.3% | 0.4222 |
| Muribaculum | 0.60 ± 0.22 | 0.13 ± 0.03 | 0.40 ± 0.15 | 0.0065 | 0.2086 | 0.0096 | 65.9% | 0.0026 |
| Odoribacter | 3.78 ± 1.89 | 2.85 ± 1.61 | 0.70 ± 0.62 | 0.2910 | 0.0065 | 0.0181 | −21.8% | 0.3337 |
| uncl. Porphyromonadaceae | 0.00 ± 0.00 | 0.02 ± 0.02 | 0.02 ± 0.03 | 0.0590 | 0.0084 | 0.6573 | 47.5% | 0.0322 |
| Parabacteroides | 0.02 ± 0.02 | 0.24 ± 0.18 | 1.64 ± 1.29 | 0.0065 | 0.0058 | 0.0162 | 23.5% | 0.2998 |
| uncl. Bacteroidales | 4.65 ± 1.58 | 7.94 ± 2.92 | 2.38 ± 0.66 | 0.0463 | 0.0133 | 0.0096 | 35.8% | 0.1074 |
| uncl. Bacteroidetes | 0.37 ± 0.12 | 0.32 ± 0.12 | 0.13 ± 0.08 | 0.3998 | 0.0089 | 0.0181 | −11.9% | 0.6376 |
| uncl. Lactobacillaceae | 0.34 ± 0.28 | 0.15 ± 0.22 | 0.04 ± 0.05 | 0.1636 | 0.0133 | 0.1983 | −38.9% | 0.0800 |
| Lactococcus | 0.98 ± 0.92 | 4.66 ± 2.19 | 0.73 ± 0.43 | 0.0074 | 0.7202 | 0.0116 | 46.6% | 0.0322 |
| uncl. Lactobacillales | 0.11 ± 0.08 | 0.19 ± 0.07 | 0.05 ± 0.06 | 0.1452 | 0.1298 | 0.0193 | 9.7% | 0.6663 |
| Clostridium_XlVa | 0.58 ± 0.36 | 1.32 ± 0.54 | 1.14 ± 0.54 | 0.0246 | 0.0442 | 0.6573 | 45.3% | 0.0354 |
| Schaedlerella | 0.02 ± 0.03 | 0.38 ± 0.26 | 0.60 ± 0.36 | 0.0067 | 0.0058 | 0.3201 | 35.6% | 0.1074 |
| Ruthenibacterium | 0.01 ± 0.02 | 0.00 ± 0.00 | 0.13 ± 0.06 | 0.1921 | 0.0058 | 0.0096 | 10.3% | 0.6663 |
| Oscillibacter | 0.22 ± 0.16 | 0.28 ± 0.10 | 0.83 ± 0.43 | 0.4392 | 0.0080 | 0.0181 | 26.6% | 0.2361 |
| uncl. Clostridiales | 1.87 ± 0.87 | 2.84 ± 1.78 | 4.49 ± 1.28 | 0.4392 | 0.0058 | 0.0974 | 44.6% | 0.0361 |
| uncl. Erysipelotrichaceae | 25.87 ± 4.88 | 11.79 ± 8.28 | 15.50 ± 9.24 | 0.0067 | 0.1998 | 0.4050 | −62.9% | 0.0034 |
| Allobaculum | 3.18 ± 1.13 | 1.58 ± 1.14 | 1.31 ± 0.62 | 0.0416 | 0.0099 | 0.7845 | −53.4% | 0.0137 |
| uncl. Alphaproteobacteria | 0.03 ± 0.05 | 0.02 ± 0.02 | 0.55 ± 0.58 | 0.7760 | 0.0302 | 0.0199 | 28.7% | 0.1998 |
| Desulfovibrio | 0.64 ± 0.50 | 0.42 ± 0.23 | 2.14 ± 0.89 | 0.4392 | 0.0133 | 0.0116 | 6.2% | 0.7791 |
Indicator taxa were identified as those with relative abundance values that differed significantly between two groups or more. Relative abundances are presented as mean ± SD and p values were adjusted for multiple testing. Correlations between indicator taxa and plasma total cholesterol was assessed using the Pearson correlation with FDR correction for multiple testing (n = 11 ND, n = 10 WD, n = 8 WD-T070 3 g/kg).