TABLE 4.

The effect estimates, test of heterogeneity, and test of pleiotropy of HCC on liver function.

Outcome	SNPs	MR methodology	Effect estimates on liver function				Test of heterogeneity		Test of pleiotropy
			OR	95%LCI	95%UCI	p-value	Cochrane Q test	Phetero-geneity	MR Egger intercept	Ppleio-tropy
ALT	rs113777417	IVW	1.031	1.009	1.054	0.005	2.600	0.273
	rs7775228	MR-Egger	1.087	1.004	1.178	0.289	0.775	0.379	−0.013	0.406
	rs8107030	Weighted median	1.029	1.000	1.059	1.1048
AST	rs113777417	IVW	1.040	1.019	1.063	2.52*10−4	1.364	0.506
	rs7775228	MR-Egger	1.004	0.927	1.086	0.943	0.509	0.475	0.009	0.525
	rs8107030	Weighted median	1.035	1.007	1.064	0.013
GGT	rs113777417	IVW	1.014	0.991	1.038	0.242	12.607	0.001
	rs7775228	MR-Egger	1.134	0.924	1.391	0.441	5.625	0.017	−0.027	0.466
	rs8107030	Weighted median	1.022	0.982	1.064	0.286
ALP	rs113777417	IVW	0.971	0.947	0.995	0.018	0.806	0.369
	rs7775228	MR-Egger	1.049	0.956	1.150	0.498	3.714	0.156	−0.019	0.338
	rs8107030	Weighted median	0.971	0.941	1.001	0.061