Table 2. Adverse events in dogs received ca-4F12-E6 (n = 37).
| Variables | All grade | Grade 1 | Grade 2 | Grade 3 | Grade 4 | |
|---|---|---|---|---|---|---|
| Treatment-related | ||||||
| Appetite, altered | 2 | 1 | 1 | 0 | 0 | |
| Fatigue | 1 | 1 | 0 | 0 | 0 | |
| Diarrhea | 5 | 4 | 1 | 0 | 0 | |
| Vomiting | 1 | 1 | 0 | 0 | 0 | |
| Colitis | 1 | 0 | 1 | 0 | 0 | |
| ALT | 3 | 0 | 1 | 0 | 2 | |
| AST | 2 | 0 | 0 | 2 | 0 | |
| ALP | 3 | 0 | 1 | 2 | 0 | |
| Bil | 1 | 1 | 0 | 0 | 0 | |
| Megaesophagusa | 1 | 0 | 1 | 0 | 0 | |
| Myasthenia gravisa | 1 | 0 | 1 | 0 | 0 | |
| Hypothyroidisma | 1 | 0 | 0 | 1 | 0 | |
| Sterile nodular panniculitis | 2 | - | ||||
| Treatment-unlikely or unrelated | ||||||
| Aspiration pneumonia | 2 | 0 | 0 | 2 | 0 | |
| BUN | 1 | 0 | 0 | 1 | 0 | |
| ALT | 3 | 0 | 0 | 2 | 1 | |
| ALP | 3 | 0 | 1 | 1 | 1 | |
| Seizure | 1 | 0 | 1 | 0 | 0 | |
| Occurring the other tumor | 2 | - | ||||
ALT, alanine transaminase; AST, aspartate transaminase; ALP, alkaline phosphatase; Bil, bilirubin; BUN, blood urine nitrogen.
aCase 27 received ca-4F12-E6 combined with toceranib.