Table 1.
Relationships between CTSC expression and clinicopathologic factors in the total population (N = 514)
| Variables | No. of patients | CTSC groups | |||
|---|---|---|---|---|---|
|
| |||||
| Low expression group (N = 257) | High expression group (N = 257) | P value | |||
| Age, years | 65.6 ± 9.7 | 65.1 ± 10.2 | 0.554 | ||
| Sex | Male | 238 (46.3) | 118 (45.9) | 120 (46.7) | 0.860 |
| Female | 276 (53.7) | 139 (54.1) | 137 (53.3) | ||
| Smoking history | Never | 165 (32.1) | 76 (29.6) | 89 (34.6) | 0.219 |
| Former or current | 349 (67.9) | 181 (70.4) | 168 (65.4) | ||
| Anatomic site | RUL | 186 (36.2) | 96 (37.4) | 90 (35.0) | 0.422 |
| RML | 21 (4.1) | 8 (3.1) | 13 (5.1) | ||
| RLL | 95 (18.5) | 42 (16.3) | 53 (20.6) | ||
| LUL | 120 (23.3) | 59 (23.0) | 61 (23.7) | ||
| LLL | 77 (15.0) | 45 (17.5) | 32 (12.5) | ||
| Unknown | 15 (2.9) | 7 (2.7) | 8 (3.1) | ||
| T stage | T1 | 170 (33.1) | 88 (34.2) | 82 (31.9) | 0.893 |
| T2 | 279 (54.3) | 139 (54.1) | 140 (54.5) | ||
| T3 | 46 (8.9) | 21 (8.2) | 25 (9.7) | ||
| T4 | 19 (3.7) | 9 (3.5) | 10 (3.9) | ||
| Lymph node metastasis | N0 | 342 (66.5) | 186 (72.4) | 156 (60.7) | 0.047* |
| N1 | 96 (18.7) | 40 (15.6) | 56 (21.8) | ||
| N2 | 74 (14.4) | 30 (11.7) | 44 (17.1) | ||
| N3 | 2 (0.4) | 1 (0.4) | 1 (0.4) | ||
| Metastasis | M0 | 489 (95.1) | 245 (95.3) | 244 (94.9) | 1.000 |
| M1 | 25 (4.9) | 12 (4.7) | 13 (5.1) | ||
*
P < 0.05 between the two categories for a given variable.
CTSC: Cathepsin C, RUL: Right Upper Lobe, RML: Right Middle Lobe, RLL: Right Lower Lobe, LUL: Left Upper Lobe, LLL: Left Lower Lobe, N0, N1, N2, N3: Lymph Node Staging (different levels of lymph node involvement), M0: No Distant Metastasis, M1: Distant Metastasis Present.