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Hypothetical mechanism showing that alterations in lipid metabolism in the brain exacerbate AD pathology by inducing oligodendrocyte abnormalities. Lipid metabolism may be altered in the AD brain, particularly in myelin or oligodendrocyte lineage cells, which may cause white matter abnormalities and/or atrophy leading to cognitive impairment. Moreover, obesity and diets containing specific lipids might exacerbate or improve AD pathology.
