Table 4.
Broad categories of proteins targeted by cGVHD IgG antibodies
| Cell surface | Autoantigens | Tumor associated | Tumor suppressor | RNA/DNA binding | Other | |
|---|---|---|---|---|---|---|
| PDGFRA | TRIM21 | APEX1 | SALL2 | TEKT2 | APEX1 | GTF2E1 |
| PDGFRB | FGFR3 | NPM1 | DNMT3A | DAPK1 | HMGB2 | MED9 |
| TOM1 | PDHA1 | MRPL1 | RFC4 | DAPK2 | NPM1 | LGALS14 |
| FGFR3 | PDGFRA | DIDO1 | TRIM44 | SEPT4 (SEPTIN4) | MRPL1 | ALDH7A1 |
| PRKCG | PDGFRB | NOB1 | PRKD3 | TPM1 | DIDO1 | PELI1 |
| SGK1 | SNCB | SART3 | PVRL3 (NECTIN3) | TPM4 | FAM120C | DNCL1 (DYNLL1) |
| ACVR1B | NPM1 | RPRD1B | ADH5 | BNIP3L | PBK1 (RSL1D1) | SERPINB10 |
| GRK3 | DTYMK | SGK1 | VBP1 | NOB1 | UBE2F | |
| NRK | GID8 | SGK3 | 1L1RN | SRPK2 | TAF9L | |
| RTN2 | PSMA5 | ECHDC1 | MCC | RPL12 | NT5C3L | |
| FAM70B (TMEM255B) | PRKG1 | HNF4 (HNF4A) | PMEPA1 | SART3 | RPAP3 | |
| MPP7 | NPY | SERPINB2 | ACVR1B | FAM50 | GIMAP6 | |
| ARHGAP17 | RELA | TXNDC5 | AGHGAP17 | MED6 | VAT1L | |
| PMEPA1 | USE1 | GRK3 | CAMK2N1 | ZIM2 | SLAIN1 | |
| PAGE5 | NRK | TSSC4 | HMG1 (HMGB1) | PPFIBP2 | ||
| PDE4A | MAP3K10 | BEND5 | C22orf33 (TEX33) | |||
| FGFR3 | FGFR1OP (CEP43) | HNF4 | CRYBB2 | |||
| SALL2 | C11orf67 (AAMDC) | |||||
| DNMT3A | MSRB3 | |||||
| RFC4 | TPH1 | |||||
| RELA | CCDC43 | |||||
| CCDC53 (WASHC3) | ||||||
Proteins uniquely targeted by plasma from patients with cGVHD are listed by gene name. Updated gene names are listed in parentheses, when relevant. Some proteins were listed in >1 category.