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. 2023 Aug 26;65(2):100434. doi: 10.1016/j.jlr.2023.100434

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© 2023 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 6 — Targeted lipidomic analysis of serum and liver from mice with selective deletion of ATGL in adipocytes. A: Experimental design to test the impact of adipose tissue lipolysis on systemic lipid metabolism and liver. Pnpla2^F/F and Pnpla2^F/F::Adipoq^CRE mice were treated with a single dose of saline or 1 mg/kg CL-316,243. B: Morphological changes in livers after saline or CL-316,243 treatment. C: Liver, iWAT, eWAT, and BAT weights corrected for body weight. D and E: Stacked graphs showing serum lipids (D) and liver lipids (E) from major lipid classes. (n = 5–7, ∗: P < 0.05, ∗∗∗: P < 0.005). ATGL, adipose tissue triglyceride lipase; iWAT, inguinal white adipose tissue; BAT, brown adipose tissue.