Fig. 7.
Inhibition of adipose tissue lipolysis prevents lipid remodeling in the liver. A: Major lipid classes in serum after 5 h of saline or CL administration (n = 5–7. B: Heatmap for all four groups in serum lipidome. C: Volcano plot of LC-MS–based FFAs from the plasma of Pnpla2F/F group. FFAs that are increased 2-fold after CL administration and have a P-value below 0.01 are labeled in red. D: Volcano plot of LC-MS–based FFAs from the plasma of Pnpla2F F::AdipoqCRE group. FFAs that are increased 2-fold after CL administration and have a P-value below 0.01 are labeled in red. E: Major lipid classes in liver after saline or CL administration. (n = 5, ∗: P < 0.05, ∗∗: P < 0.01, ∗∗∗: P < 0.005). E: Heatmap for all four groups in liver lipidome. F: Heat map highlighting liver lipid changes after saline or CL administration.