Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jan 22;14:1265469. doi: 10.3389/fimmu.2023.1265469

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2024 Lim, Marques Da Costa, Godefroy, Jacquet, Gragert, Rondof, Marchais, Nhiri, Dalfovo, Viard, Labaied, Khan, Dessen, Romanel, Pasqualini, Schleiermacher, Carrington, Zitvogel, Scoazec, Geoerger and Salmon

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Representative examples of HLA class I immunostaining in advanced pediatric solid tumors. All tumor cells in a case of Ewing sarcoma (A) and a case of ependymoma (B) are homogeneously and strongly labeled by anti-HLA class I antibody (V, tumor vessel). In (C) all tumor cells in this other case of Ewing sarcoma are reactive with anti-HLA class I antibody but with variable apparent levels of intensity (V, tumor vessel as internal control). In a case of HGG (D) and in a case of osteosarcoma (E), HLA class I shows a patchy expression in tumor cells (V, tumor vessel; arrowheads, immune cells). In this case of nephroblastoma (F), HLA class I is strongly expressed by mesenchymal cells (M) and tubular epithelial structures (arrowheads) but is undetectable in undifferentiated blastema cells. In a case of neuroblastoma (G) and a case of rhabdomyosarcoma (H), HLA class I is undetectable on tumor cells while immune cells (arrowheads) and tumor vessels (V) are labeled. Indirect immunoperoxidase with nuclear counterstaining by hematoxylin. Original magnifications: (A–C) x220; (D) x280; (E) x220; (F) x180; (G) x320; (H) x280.