Fig. 2.

Cortical depth analysis. Line graphs display positive (A, B) or negative (C, D) susceptibility as a function of cortical depth, separately for the left (LH) or right (RH) hemisphere. Participants with AD are shown in black, and control participants in gray. Error bars represent the standard error of the mean. Moderation analyses examined whether the regression coefficient (β) was significant for group, depth, and their interaction, with significant effects surviving false discovery rate correction for multiple comparisons. For both groups, there were significant increases in positive susceptibility and decreases in negative susceptibility as depth increased from the pial surface to the GM/WM boundary. For positive susceptibility, this increase was significantly larger in the LH for participants with AD and in the RH for control participants. Susceptibility is measured in parts per million (ppm).