Table 2.

Diagnosis and grading of severity of acute-on-chronic liver failure

ACLF grade	Criteria
No ACLF	(a) Patients with no organ failure (b) Patients with single hepatic, coagulation, circulatory, or respiratory failure with serum creatinine <1.5 mg/dL, and no HE (c) Patients with cerebral failure and serum creatinine <1.5 mg/dL
ACLF grade I	(a) Patients with renal failure (b) Patients with other single organ failure with serum creatinine between 1.5 and 1.9 mg/dL and HE grades I–II (c) Patients with single cerebral failure and serum creatinine levels between 1.5 and 1.9 mg/dL
ACLF grade II	Patients with two-organ failures
ACLF grade III	Patients with three or more organ failures

ACLF, acute-on-chronic liver failure; HE, hepatic encephalopathy