Table 2.

Psoriasis IVs for pleiotropy and heterogeneity testing in relation to central nervous system disorders GWAS.

Outcomes	Pleiotropy analysis			Heterogeneity analysis
	MR-Egger			MR-Egger			Inverse-variance weighted
	Intercept	SE	P	Q	Q_df	Q_pval	Q	Q_df	Q_pval
migraine	−4.60E-05	0.14E-03	0.74	19.96	16.00	0.22	20.10	17.00	0.27
Parkinson's Disease	2.00E-04	0.01	0.99	9.73	15.00	0.84	9.73	16.00	0.88
multiple sclerosis	−0.01	0.03	0.79	19.05	10.00	0.04	19.19	11.00	0.06
epilepsy	−0.01	0.01	0.34	15.24	9.00	0.09	16.97	10.00	0.08

df, degree of freedom; MR, Mendelian randomization; Q, heterogeneity statistic Q.