Table 3.

Structural brain changes in the SA vs HC and SA vs MAD groups.

SA vs HC	GMV	Decreased: in the left and right DLPFC, OFC, ventral/medial PFC, amygdala; in the right VLPFC, the middle temporal gyrus; Increased: in the right parietal lobe.
	Gray Matter Density	Decreased: in the VMPFC.
SA vs MAD	GMV	Decreased: in the left and right DLPFC, ventral/medial PFC, amygdala, hippocampus; in the right VLPFC, inferior frontal orbital gyrus; in the left caudate, angular gyrus, limbic cingulate gyrus; Increased: in the PFC regions, insula and the right amygdala.
	Cortical Thickness	Decreased: in the left DLPFC, VLPFC, fronto-parietal regions, insula; and the anterior cingulate.
	Gray Matter Density	Increased: in the left striatum.

DLPFC: dorsolateral prefrontal cortex; GMV: gray matter volume; HC: healthy control; MAD: middle-aged depression; OFC: orbital frontal cortex; PFC: prefrontal cortex; SA: suicide attempts; VLPFC: ventrolateral prefrontal cortex; VMPFC: ventromedial prefrontal cortex.